Evaluation of Overall Survival and its Influencing Factors in Patients with Chronic Lymphocytic Leukemia in West of Iran in 1998-2016

Chronic lymphocytic leukemia (CLL) is a type of lymphoid neoplasms that occurs with the accumulation of clonal b-cell lymphocytes in organs such as bone marrow, blood and lymph nodes [1]. This leukemia is one of the most common leukemia in western countries which appear in adults, however; the prevalence of CLL in eastern countries is lower than western countries [2,3]. However, this malignancy includes about 19,000 cases of all newly diagnosed cases of cancer in the United States in 2016 [4]. One of the most important pathophysiological causes in CLL patients is genetic variation that is very widespread, as well as chromosomal alterations in at least 80% of these patients in one of the following forms. Chromosomal alterations: a deletion in chromosome 13q14.3 (del 13q), del (11q), del (17p) and trisomy 12 [5,6].